Dr. M. M. B. Sharma’s research focuses on the development and application of advanced polymer-based drug delivery systems, aiming to enhance therapeutic outcomes for conditions such as diabetes, cancer, sleep disorders, and bacterial infections. His work explores the use of poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel microneedles for the transdermal delivery of metformin, demonstrating how optimizing the composition of these microneedles can improve drug release profiles and penetration capabilities. Additionally, he investigates the potential of pHEMA microneedles for delivering bioactives like estradiol, melatonin, and meropenem, showcasing their versatility in treating a range of medical conditions through minimally invasive methods.

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Further research by Dr. Sharma explores stimuli-responsive systems, particularly polypyrrole-based interpenetrating polymer networks (IPNs) for controlled release of melatonin. These films, engineered with biopolymers such as sodium hyaluronate and pectin, offer tailored drug release profiles, presenting significant promise for the treatment of sleep disorders.

Additionally, Dr. Sharma introduces a smart dual-mode device for melatonin delivery, integrating light-dependent resistance (LDR) and circadian rhythm (CR) systems to synchronize drug release with the body’s natural sleep-wake cycles. This innovation represents a major step toward personalized medicine, ensuring more precise and adaptive therapeutic solutions.

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In conclusion, Dr. M. M. B. Sharma’s research pioneers innovative polymer-based platforms for transdermal and controlled drug delivery, demonstrating their potential to revolutionize treatment methods for a variety of medical conditions through personalized, minimally invasive systems.